Protein tyrosine phosphatase–σ regulates hematopoietic stem cell–repopulating capacity
نویسندگان
چکیده
منابع مشابه
Protein tyrosine phosphatase-σ regulates hematopoietic stem cell-repopulating capacity.
Hematopoietic stem cell (HSC) function is regulated by activation of receptor tyrosine kinases (RTKs). Receptor protein tyrosine phosphatases (PTPs) counterbalance RTK signaling; however, the functions of receptor PTPs in HSCs remain incompletely understood. We found that a receptor PTP, PTPσ, was substantially overexpressed in mouse and human HSCs compared with more mature hematopoietic cells....
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Comment on: Campaner S, et al. Cell Cycle 2013; 12;3663–72; PMID:24091730; http://dx.doi.org/10.4161/cc.26584 Senthil Raja Jayapal and Philipp Kaldis; Institute of Molecular and Cell Biology (IMCB); A*STAR (Agency for Science, Technology and Research); Singapore, Republic of Singapore; National University of Singapore (NUS); Department of Biochemistry; Singapore, Republic of Singapore; *Email: ...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 2014
ISSN: 0021-9738
DOI: 10.1172/jci77866